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Data-independent acquisition (DIA) proteomics sequencing of tMCAO rat brain

ABSTRACT: To investigate the role of the Jak2/Stat3 pathway in acute cerebral ischemia-reperfusion injury (CIRI), we employed AAV9-mediated gene silencing in a tMCAO rat model. Specifically, AAV9-shNC (control) or AAV9-shJak2 (knockdown) was administered, and analyses were performed at 2 days post-surgery. To further identify downstream targets of Jak2/Stat3 signaling under tMCAO conditions, we conducted DIA proteomics sequencing to compare protein expression profiles between tMCAO+shNC and tMCAO+shJak2 rats.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Haitong Wan

PROVIDER: PXD079863 | iProX | Thu Jun 18 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX

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