Harnessing the E3 Ligase KLHL12 for Tumor-selective Protein Degradation via Proteolysis-targeting Chimera Technology
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ABSTRACT: This project harnesses the E3 ligase KLHL12 for tumor-selective protein degradation. We designed and synthesized novel PROTACs , characterized their binding affinity and selectivity by biochemical assays, and performed quantitative proteomics to systematically evaluate degradation specificity, kinetics, and anti-tumor efficacy in cancer cell models.
ORGANISM(S): Homo Sapiens
SUBMITTER:
Zhengyu Jiang
PROVIDER: PXD082322 | iProX | Fri Aug 07 00:00:00 GMT+01:00 2026
REPOSITORIES: iProX
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