Proteomics

Dataset Information

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Harnessing the E3 Ligase KLHL12 for Tumor-selective Protein Degradation via Proteolysis-targeting Chimera Technology


ABSTRACT: This project harnesses the E3 ligase KLHL12 for tumor-selective protein degradation. We designed and synthesized novel PROTACs , characterized their binding affinity and selectivity by biochemical assays, and performed quantitative proteomics to systematically evaluate degradation specificity, kinetics, and anti-tumor efficacy in cancer cell models.

ORGANISM(S): Homo Sapiens

SUBMITTER: Zhengyu Jiang  

PROVIDER: PXD082322 | iProX | Fri Aug 07 00:00:00 GMT+01:00 2026

REPOSITORIES: iProX

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