Acetylation of p73 in 293T cell
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Tetsu Akiyama
PROVIDER: PXD010411 | JPOST Repository | Mon Sep 10 00:00:00 BST 2018
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 140306iwa_Hayashi1_65min_TOP20_4ul.msf | Msf | |||
| 140306iwa_Hayashi1_65min_TOP20_4ul.raw | Raw | |||
| 140306iwa_Hayashi1_65min_TOP20_4ul.xlsx | Xlsx |
Items per page: 5 1 - 3 of 3 |
Publications
SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity.
Funato Kosuke K Hayashi Tomoatsu T Echizen Kanae K Negishi Lumi L Shimizu Naomi N Koyama-Nasu Ryo R Nasu-Nishimura Yukiko Y Morishita Yasuyuki Y Tabar Viviane V Todo Tomoki T Ino Yasushi Y Mukasa Akitake A Saito Nobuhito N Akiyama Tetsu T
EMBO reports 20180913 11
Glioblastoma is one of the most aggressive forms of cancers and has a poor prognosis. Genomewide analyses have revealed that a set of core signaling pathways, the p53, RB, and RTK pathways, are commonly deregulated in glioblastomas. However, the molecular mechanisms underlying the tumorigenicity of glioblastoma are not fully understood. Here, we show that the lysine deacetylase SIRT2 is required for the proliferation and tumorigenicity of glioblastoma cells, including glioblastoma stem cells. Fu ...[more]
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