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Mice kidney cortex proteome

ABSTRACT: O-GlcNAcylation is a global post translational modification. The purpose of this study is to investigate the role of O-GlcNAcylation in mice kidney proximal tubules. We used drug-inducible proximal tubular cells specific O-GlcNAc transferase (Ogt) KO mice (PTEC-Ogt KO). In this proteomic analysis, we compared kidney cortex from fasted PTEC-Ogt KO and Control mice.

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Sho Sugahara

PROVIDER: PXD012456 | JPOST Repository | Fri May 17 00:00:00 BST 2019

REPOSITORIES: jPOST

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Protein O-GlcNAcylation Is Essential for the Maintenance of Renal Energy Homeostasis and Function <i>via</i> Lipolysis during Fasting and Diabetes.

Sugahara Sho S Kume Shinji S Chin-Kanasaki Masami M Tomita Issei I Yasuda-Yamahara Mako M Yamahara Kosuke K Takeda Naoko N Osawa Norihisa N Yanagita Motoko M Araki Shin-Ichi SI Maegawa Hiroshi H

Journal of the American Society of Nephrology : JASN 20190501 6

<h4>Background</h4>Energy metabolism in proximal tubular epithelial cells (PTECs) is unique, because ATP production largely depends on lipolysis in both the fed and fasting states. Furthermore, disruption of renal lipolysis is involved in the pathogenesis of diabetic tubulopathy. Emerging evidence suggests that protein O-GlcNAcylation, an intracellular nutrient-sensing system, may regulate a number of metabolic pathways according to changes in nutritional status. Although O-GlcNAcylation in PTEC ...[more]

PMID: 31043434

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