Dataset Information
The ABCF proteins in Escherichia coli individually address "hard-to-translate" nascent peptide sequences.
Ontology highlight
ABSTRACT:
ORGANISM(S): Escherichia Coli
SUBMITTER: Yuhei Chadani
PROVIDER: PXD049710 | JPOST Repository | Fri Apr 26 00:00:00 BST 2024
REPOSITORIES: jPOST
Publications
The ABCF proteins in Escherichia coli individually cope with 'hard-to-translate' nascent peptide sequences.
Nucleic acids research 20240425
Organisms possess a wide variety of proteins with diverse amino acid sequences, and their synthesis relies on the ribosome. Empirical observations have led to the misconception that ribosomes are robust protein factories, but in reality, they have several weaknesses. For instance, ribosomes stall during the translation of the proline-rich sequences, but the elongation factor EF-P assists in synthesizing proteins containing the poly-proline sequences. Thus, living organisms have evolved to expand ...[more]
