Dataset Information

Mass spectrometry-based proteomic approach to colorectal cancer identified the cancer-associated proteins whose expression changes with the disease progression

ABSTRACT: Tumor and non-tumor tissues from 19 cases of colorectal cancer were examined using DIA-based mass spectrometry. A total of 11,833 proteins were identified, including 531 of the 748 cancer-associated proteins defined in the Catalogue of Somatic Mutations in Cancer. In the comparative analysis between the tumor and non-tumor tissue groups, we observed a significant number of differentially expressed proteins, some of which consistently increased or decreased with disease progression.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Yuki Yoshimatsu

PROVIDER: PXD058672 | JPOST Repository | Tue Aug 26 00:00:00 BST 2025

REPOSITORIES: jPOST

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Publications

Identification of Cancer-Associated Proteins in Colorectal Cancer Using Mass Spectrometry.

Toyota Naoyuki N Konno Ryo R Iwata Shuhei S Fujita Shin S Kodera Yoshio Y Noguchi Rei R Kondo Tadashi T Kawashima Yusuke Y Yoshimatsu Yuki Y

Proteomes 20250812 3

<h4>Background</h4>Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with a multifactorial etiology involving genetic and environmental factors. Advanced proteomics offers valuable insights into the molecular mechanisms of cancer, identifying proteins that function as mediators in tumor biology.<h4>Methods</h4>In this study, we used mass spectrometry-based data-independent acquisition (DIA) to analyze the proteomic landscape of CRC. We compared protein abundance i ...[more]

PMID: 40843711

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	CRC06-T.raw	Raw
	CRC07-N.raw	Raw
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	CRC08-N.raw	Raw
	CRC08-T.raw	Raw