Dataset Information
Calmodulin and CHK2 kinase crosslinking
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Prof. James Murphy
PROVIDER: PXD062332 | JPOST Repository | Sat Mar 28 00:00:00 GMT 2026
REPOSITORIES: jPOST
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| P4171_01.mgf | Mgf | |||
| P4171_01.raw | Raw | |||
| P4171_02.mgf | Mgf | |||
| P4171_02.raw | Raw | |||
| P4171_03.mgf | Mgf |
Items per page: 1 - 5 of 20 |
Publications
Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity.
The Biochemical journal 20251201 23
Calmodulin (CaM) serves an essential role in eukaryotic cells as a Ca2+ sensor. Ca2+ binding leads to conformation changes in CaM that enable engagement of a repertoire of enzymes and the regulation of their catalytic activities. Classically, Ca2+-CaM binds to an inhibitory pseudosubstrate sequence C-terminal to the kinase domain in members of the Ca2+-CaM-dependent protein kinase (CAMK) family and relieves inhibition to promote catalytic activity. Here, we report an unexpected mechanism by whic ...[more]
