Proteomics

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Proteome analysis of human postmortem brain tissues in tauopathies, including corticobasal degeneration, progressive supranuclear palsy, and Alzheimer's disease

ABSTRACT: Tauopathies are a group of neurodegenerative diseases characterised by the abnormal accumulation of tau protein within neural and glial cells. The molecular mechanisms of tauopathies remain poorly understood. To identify proteins whose abundance is altered by the disease group, we performed a proteomic analysis of brain homogenate from patients with three tauopathy-related diseases: corticobasal degeneration, progressive supranuclear palsy and Alzheimer's disease.

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Takeshi Ikeuchi 

PROVIDER: PXD072806 | JPOST Repository | Sat May 09 00:00:00 BST 2026

REPOSITORIES: jPOST

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Publications

Mass spectrometry-based proteomic profiling of human tauopathy brains suggests mitochondria-associated alterations.

Jannah Alfi Raudatil AR   Hasegawa Mai M   Ham Jonathan J   Hara Norikazu N   Tsukie Tamao T   Obinata Ai A   Kikuchi Masataka M   Kasuga Kensaku K   Yamaguchi Haruyasu H   Hamasaki Hideomi H   Tada Mari M   Kakita Akiyoshi A   Matsumoto Masaki M   Miyashita Akinori A   Ikeuchi Takeshi T  

Frontiers in molecular neuroscience 20260522

Tauopathies are neurodegenerative disorders characterized by intracellular accumulation of abnormal tau encoded by <i>MAPT</i>, yet their molecular mechanisms remain incompletely understood. We aimed to identify proteomic signatures associated with the primary tauopathies corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), as well as the secondary tauopathy Alzheimer's disease (AD), and to characterize their interaction networks. Total homogenates from the specified cortica  ...[more]

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