Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-um spatial resolution
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Mus Musculus (ncbitaxon:10090)
SUBMITTER: 
Kristin Burnum-Johnson
PROVIDER: MSV000084421 | MassIVE | Fri Oct 04 13:16:00 BST 2019
REPOSITORIES: MassIVE
Publications
Automated mass spectrometry imaging of over 2000 proteins from tissue sections at 100-μm spatial resolution.
Piehowski Paul D PD Zhu Ying Y Bramer Lisa M LM Stratton Kelly G KG Zhao Rui R Orton Daniel J DJ Moore Ronald J RJ Yuan Jia J Mitchell Hugh D HD Gao Yuqian Y Webb-Robertson Bobbie-Jo M BM Dey Sudhansu K SK Kelly Ryan T RT Burnum-Johnson Kristin E KE
Nature communications 20200107 1
Biological tissues exhibit complex spatial heterogeneity that directs the functions of multicellular organisms. Quantifying protein expression is essential for elucidating processes within complex biological assemblies. Imaging mass spectrometry (IMS) is a powerful emerging tool for mapping the spatial distribution of metabolites and lipids across tissue surfaces, but technical challenges have limited the application of IMS to the analysis of proteomes. Methods for probing the spatial distributi ...[more]
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