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Zika virus infection activates cellular immune responses in Sertoli cells and dysregulates proteins involved in carbohydrate metabolism and cardiovascular disease

ABSTRACT: Zika virus (ZIKV) causes congenital brain abnormalities and Guillain-Barre syndrome. It mainly transmits by Aedes mosquitoes, but infections also are linked to sexual transmissions. ZIKV can proliferate in human Sertoli cells (HSerC) for several weeks in vitro, suggesting that it might be a reservoir for persistent ZIKV infection. This study determined the proteomic changes in HSerC during ZIKV infections by TMT-mass spectrometry analysis. In Sertoli cells, a total of 4416 unique proteins were significantly dis-regulated across 3, 5, and 7 days after ZIKV infection. The dis-regulated proteins include enzymes, transcription regulators, transporters, kinases, peptidases, transmembrane receptors, cytokines, ion channels, and growth factors. Many of those proteins are involved in antiviral response, antigen presentation, and immune cell activation.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Kevin Coombs

PROVIDER: MSV000088634 | MassIVE | Tue Jan 04 05:24:00 GMT 2022

REPOSITORIES: MassIVE

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