Identification of non-conventional small molecule degraders and stabilizers of squalene synthase

ABSTRACT: The dataset was obtained by performing a TMTpro16plex expression proteomics experiment, where HeLa cells were treated with small molecule ligands of squalene synthase (FDFT1). The experiment was successful in re-producing previously obtained Western Blot results in regards to SQS (=FDFT1) levels and aimed at elucidating downstream effects on cholesterol biosynthesis and metabolism. The dataset comprises data for the following samples: DMSO (vehicle), KY02111, PROTAC 18, SQSI and a compound unrelated to this project (TMTpro16plex, processed by Maxquant, each collected in 30 fractions). The experiments were performed in three independent replicates for each compound (R1-R3).

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Luca laraia  

PROVIDER: MSV000093137 | MassIVE | Wed Oct 18 01:04:00 BST 2023

REPOSITORIES: MassIVE