MEF2A, MEF2C, and MEF2D Interactomes in Mouse MA-10 Leydig Cells

ABSTRACT: In steroidogenic Leydig cells, MEF2A, MEF2C, and MEF2D are key regulators of genes involved in steroid hormone synthesis, reproductive function, and oxidative stress defense. Here we used TurboID proximity-mediated biotinylation to map the protein-protein interaction networks of MEF2A, MEF2C, and MEF2D in mouse MA-10 Leydig cells. Interactions were captured under both basal (unstimulated) and forskolin-stimulated conditions to examine differences in the MEF2 interactomes in relation to steroidogenesis. This dataset provides insights into MEF2-related signalling pathways and the functional landscape of MEF2 transcription factors in Leydig cells.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (ncbitaxon:10090)

SUBMITTER: Jacques J Tremblay  

PROVIDER: MSV000096432 | MassIVE | Fri Nov 15 12:57:00 GMT 2024

SECONDARY ACCESSION(S): PXD057949

REPOSITORIES: MassIVE