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Mass Spectrometry-Driven Epitope Mapping: Application of Diethylpyrocarbonate Covalent Labeling for the Immunotherapeutic Target Programmed Cell Death Protein 1

ABSTRACT: Monoclonal antibodies (mAbs) have transformed cancer immunotherapy, with anti-PD1 mAbs playing a pivotal role. This study introduces diethylpyrocarbonate covalent labeling-mass spectrometry (DEPC CL-MS) as a rapid and sensitive technique for epitope mapping of PD1, a critical target in mAb development.

INSTRUMENT(S): QExactive LCMS

ORGANISM(S): Homo Sapiens (ncbitaxon:9606)

SUBMITTER: Patanachai Limpikirati

PROVIDER: MSV000096536 | MassIVE | Tue Nov 26 19:31:00 GMT 2024

REPOSITORIES: MassIVE

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