Metabolomic Responses to Circadian Rhythm Disruption in Zebrafish

ABSTRACT:

Circadian rhythms are essential biological oscillators that synchronize physiological processes, cellular homeostasis, and systemic metabolism with the Earth's natural 24-hour light-dark cycle. While circadian rhythm disruption (CRD) is highly prevalent in modern society due to factors such as shift work, frequent time-zone transitions (jet lag), and artificial illumination, its specific impact on the metabolic landscape during early organismal and brain development remains poorly understood. To investigate the biochemical consequences of circadian misalignment during critical developmental windows, we utilized the zebrafish (Danio rerio) as a diurnal vertebrate model. We established a specific developmental 'jet lag' paradigm by subjecting zebrafish to repeated photoperiod phase shifts across their embryonic and early larval stages. This dataset comprises the raw metabolomic profiling data obtained from these experimental and control samples.

INSTRUMENT(S): Liquid Chromatography MS - alternating - hilic

PROVIDER: MTBLS14815 | MetaboLights | 2026-06-23

REPOSITORIES: MetaboLights