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Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice - Plasma (part V)

ABSTRACT: Characterization and analysis of metabolomic, proteomic and metabolic profiles of C57/Bl6N mice fed various high fat diets

ORGANISM(S): Mouse Mus Musculus

TISSUE(S): Blood

DISEASE(S): Obesity

SUBMITTER: Jun Yang

PROVIDER: ST000901 | MetabolomicsWorkbench | Wed Jul 26 00:00:00 BST 2017

REPOSITORIES: MetabolomicsWorkbench

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Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity

Project description:Soybean oil consumption is increasing worldwide and parallels the obesity epidemic in the U.S. Rich in unsaturated fats, especially linoleic acid, soybean oil is assumed to be healthy, and yet it induces obesity, diabetes, insulin resistance and fatty liver in mice. The genetically modified soybean oil Plenish came on the U.S. market in 2014: it is low in linoleic acid and similar to olive oil in fatty acid composition. Here we show that Plenish induces less obesity than conventional soybean oil: metabolomics, proteomics and a transgenic mouse model implicate oxylipin metabolites of omega-6 and omega-3 fatty acids (linoleic and α-linolenic acid, respectively), which are generated by target genes of nuclear receptor HNF4α. While Plenish induces less insulin resistance than conventional soybean oil, it results in hepatomegaly and liver dysfunction as does olive oil. Altering the fatty acid profile of soybeans could help reduce obesity but may also cause liver complications.

2017-03-20 | GSE79408 | GEO

Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice - Liver (part VI)

Project description:Characterization and analysis of metabolomic, proteomic and metabolic profiles of C57/Bl6N mice fed various high fat diets

2017-07-26 | ST000902 | MetabolomicsWorkbench

Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice.

Project description: Not available

| S-EPMC5624939 | biostudies-literature

Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice

Project description:Soybean oil consumption is increasing worldwide and parallels the rise in obesity. Rich in unsaturated fats, especially linoleic acid, soybean oil is assumed to be healthy, and yet it induces obesity, diabetes, insulin resistance and fatty liver in mice. Here, we show that the genetically modified soybean oil Plenish, which came on the U.S. market in 2014 and is low in linoleic acid, induces less obesity than conventional soybean oil in C57BL/6male mice.

2017-06-08 | MSV000081149 | MassIVE

Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice (part IV)

Project description:In this study we have compared the metabolic effects of conventional soybean oil to those of genetically modified Plenish soybean oil, that is low in linoleic acid and high in oleic acid. This work builds on our previous study showing that soybean oil, rich in polyunsaturated fats, is more obesogenic and diabetogenic than coconut oil, rich in saturated fats (PMID: 26200659). Here, in order to elucidate the mechanisms responsible for soybean oil induced obesity, we have performed the first ever metabolomics (in plasma and liver) and proteomics on the livers of mice fed the two soybean oil diets (plus those fed a high coconut oil and Viv chow diet). Our results show that the new high oleic soybean oil induces less obesity and adiposity than conventional soybean oil, but can cause hepatomegaly and liver dysfunction. Metabolomic analysis reveals that the hepatic and plasma metabolic profiles differ considerably between the two soybean oils. Hepatic C18 oxylipin metabolites of omega-6 (ω6) and omega-3 (ω3) fatty acids (linoleic and α-linolenic acid, respectively) in the cytochrome P450/soluble epoxide hydrolase pathway were found to correlate positively with obesity.

2017-06-23 | ST000658 | MetabolomicsWorkbench

Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice (part III)

2017-06-23 | ST000656 | MetabolomicsWorkbench

Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice (part II)

2017-06-22 | ST000655 | MetabolomicsWorkbench

Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice (part I)

2017-06-22 | ST000660 | MetabolomicsWorkbench

lncRNAs expression in the liver of large yellow croaker fed with fish oil, soybean oil, olive oil, and palm oil diets

Project description:To investigate the role of lncRNAs on lipid metabolism, we did RNAseq to find the difference among large yellow croaker fed with fish oil (FO), soybean oil (SO), olive oil (OO), and palm oil (PO) diets

2022-07-05 | GSE186012 | GEO

RNAseq of prostate from mice submitted to diets containing different fatty acids profile (pork fat, linseed oil and soybean oil)

Project description:To perform mRNA expression analysis through deep sequencing, RNA was isolated from prostate mice treated with normolipidic diets based on linseed oil, soybean oil or lard (varying saturated and unsaturated FA contents and ω-3/ω-6 ratios (ω ratio) for 12 or 32 weeks after weaning

2020-04-14 | GSE131143 | GEO

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