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Metabolomic profiling of the rat hippocampus across developmental ages and after learning

ABSTRACT: Little is known about how the hippocampal metabolomic profile changes across development and in response to learning at different ages. To fill this knowledge gap, we employed an untargeted metabolomic analyses in rats to determine how the hippocampal metabolome changes over the course of post-natal development under basal conditions and following inhibitory avoidance (IA) training, an aversive episodic event. We found that unique metabolomic profiles accompany learning at different ages. Subsequent biochemical and behavioral studies based on unique metabolomic regulations in the infant hippocampus established that infantile learning selectively recruits the glutathione-mediated antioxidant defenses for the formation of infantile memory.

ORGANISM(S): Rat Rattus Norvegicus

TISSUE(S): Brain

SUBMITTER: Benjamin Bessieres

PROVIDER: ST001745 | MetabolomicsWorkbench | Fri Mar 26 00:00:00 GMT 2021

REPOSITORIES: MetabolomicsWorkbench

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