Genomics,Multiomics

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SNP and STR Analysis of "ZZ" and "HH" Generated by SCNT Using Fetal Fibroblasts


ABSTRACT: Single-nucleotide polymorphisms (SNPs) and short tandem repeats (STR) analysis for "ZZ", "HH" and corresponding nuclear donor cells, oocyte donor cells, surrogate monkeys.

SUBMITTER: Sun,Qiang 

PROVIDER: OEX000103 | NODE |

REPOSITORIES: NODE

Dataset's files

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Action DRS
1517630048320.fsa Other
1517630048343.fsa Other
1517630048353.fsa Other
1517630048359.fsa Other
1517630069175.fsa Other
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Publications


Generation of genetically uniform non-human primates may help to establish animal models for primate biology and biomedical research. In this study, we have successfully cloned cynomolgus monkeys (Macaca fascicularis) by somatic cell nuclear transfer (SCNT). We found that injection of H3K9me3 demethylase Kdm4d mRNA and treatment with histone deacetylase inhibitor trichostatin A at one-cell stage following SCNT greatly improved blastocyst development and pregnancy rate of transplanted SCNT embryo  ...[more]

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