Genomics

Dataset Information

0

Rattus norvegicus


ABSTRACT: Genomic Studies upon NeuroD6 overexpression in PC12 cells, in the presence or absence of an apoptotic stimulus

ORGANISM(S): Rattus norvegicus  

PROVIDER: PRJNA116993 | ENA |

REPOSITORIES: ENA

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Publications

NeuroD6 genomic signature bridging neuronal differentiation to survival via the molecular chaperone network.

Uittenbogaard Martine M   Baxter Kristin K KK   Chiaramello Anne A  

Journal of neuroscience research 20100101 1


During neurogenesis, expression of the basic helix-loop-helix NeuroD6/Nex1/MATH-2 transcription factor parallels neuronal differentiation and is maintained in differentiated neurons in the adult brain. To dissect NeuroD6 differentiation properties further, we previously generated a NeuroD6-overexpressing stable PC12 cell line, PC12-ND6, which displays a neuronal phenotype characterized by spontaneous neuritogenesis, accelerated NGF-induced differentiation, and increased regenerative capacity. Fu  ...[more]

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