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Mus musculus

ABSTRACT: Gene Expression Analysis of Ara-C Resistance in AML

OTHER RELATED OMICS DATASETS IN: E-GEOD-18322

PROVIDER: PRJNA117975 | ENA |

REPOSITORIES: ENA

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Gene expression signatures in ex vivo Cytarabine (Ara-C) and Daunorubicin (Dnr) sensitive AML samples

Project description:Wide inter-individual variation in terms of outcome and toxic side effects of treatment exist among patients with AML receiving chemotherapy with cytarabine (Ara-C) and daunorubicin (Dnr). Drug resistance and relapse are considered major causes of treatment failure. Gene expression profiling was undertaken to address possible mechanisms of Ara-C/Dnr resistance. Based on ex vivo Ara-C cytotoxicity at diagnosis, Ara-C sensitive (IC50 <3uM AraC) and Dnr sensitive samples (IC50 < 0.5 uM) (5 samples each) were included for microarray analysis. These were compared with the samples which were drug resistant ex vivo at diagnosis. Our microarray experiment resulted in indentifying differentially expressed genes under ex vivo Ara-C sensitive as well as Dnr sensitive samples compared to ex vivo Drug resistant samples.

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Mus musculus

Project description:Transcriptome Sequencing (RNA-seq) of Ara-C Resistant Murine AML Cell Lines Identifies Mechanisms of Resistance

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RETRACTED BY AUTHORS

Project description:Title: Gene Expression in Ara-C Resistance in AML A microarray study of altered gene expression in acute myeloid leukemia cell lines Keywords: cell type comparison Keywords: Expression profiling by array

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