Dataset Information


Mus musculus

ABSTRACT: Expression data from (bezafibrate treated-wild type, Clock mutant, and PPARalpha-null) mouse liver

ORGANISM(S): Mus musculus  



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Bezafibrate induces plasminogen activator inhibitor-1 gene expression in a CLOCK-dependent circadian manner.

Oishi Katsutaka K   Koyanagi Satoru S   Matsunaga Naoya N   Kadota Koji K   Ikeda Eriko E   Hayashida Satoru S   Kuramoto Yukako Y   Shimeno Hiroshi H   Soeda Shinji S   Ohdo Shigehiro S  

Molecular pharmacology 20100416 1

A functional interaction between peroxisome proliferator-activated receptor alpha (PPARalpha) and components of the circadian clock has been suggested, but whether these transcriptional factors interact to regulate the expression of their target genes remains obscure. Here we used a PPARalpha ligand, bezafibrate, to search for PPARalpha-regulated genes that are expressed in a CLOCK-dependent circadian manner. Microarray analyses using hepatic RNA isolated from bezafibrate treated-wild type, Cloc  ...[more]

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