Genomics

Dataset Information

118

Drosophila melanogaster


ABSTRACT: Polycomb preferentially targets stalled promoters of coding and non-coding transcripts

ORGANISM(S): Drosophila melanogaster  

PROVIDER: PRJNA132651 | ENA |

REPOSITORIES: ENA

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Publications

Polycomb preferentially targets stalled promoters of coding and noncoding transcripts.

Enderle Daniel D   Beisel Christian C   Stadler Michael B MB   Gerstung Moritz M   Athri Prashanth P   Paro Renato R  

Genome Research 20101222 2


The Polycomb group (PcG) and Trithorax group (TrxG) of proteins are required for stable and heritable maintenance of repressed and active gene expression states. Their antagonistic function on gene control, repression for PcG and activity for TrxG, is mediated by binding to chromatin and subsequent epigenetic modification of target loci. Despite our broad knowledge about composition and enzymatic activities of the protein complexes involved, our understanding still lacks important mechanistic de  ...[more]

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