Dataset Information


Mus musculus

ABSTRACT: Liver gene expression in animals with hepatocyte-specific deletion of JAK2

ORGANISM(S): Mus musculus  



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Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.

Sos Brandon C BC   Harris Charles C   Nordstrom Sarah M SM   Tran Jennifer L JL   Balázs Mercedesz M   Caplazi Patrick P   Febbraio Maria M   Applegate Milana A B MA   Wagner Kay-Uwe KU   Weiss Ethan J EJ  

The Journal of clinical investigation 20110401 4

Non-alcoholic fatty liver disease is associated with multiple comorbid conditions, including diabetes, obesity, infection, and malnutrition. Mice with hepatocyte-specific disruption of growth hormone (GH) signaling develop fatty liver (FL), although the precise mechanism underlying this finding remains unknown. Because GH signals through JAK2, we developed mice bearing hepatocyte-specific deletion of JAK2 (referred to herein as JAK2L mice). These mice were lean, but displayed markedly elevated l  ...[more]

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