Dataset Information


Mus musculus

ABSTRACT: Matrix metalloproteinase-9 and TIMP-1 in peripheral nerve: Implications for myelin formation

ORGANISM(S): Mus musculus  



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The MMP-9/TIMP-1 axis controls the status of differentiation and function of myelin-forming Schwann cells in nerve regeneration.

Kim Youngsoon Y   Remacle Albert G AG   Chernov Andrei V AV   Liu Huaqing H   Shubayev Igor I   Lai Calvin C   Dolkas Jennifer J   Shiryaev Sergey A SA   Golubkov Vladislav S VS   Mizisin Andrew P AP   Strongin Alex Y AY   Shubayev Veronica I VI  

PloS one 20120316 3

BACKGROUND:Myelinating Schwann cells (mSCs) form myelin in the peripheral nervous system. Because of the works by us and others, matrix metalloproteinase-9 (MMP-9) has recently emerged as an essential component of the Schwann cell signaling network during sciatic nerve regeneration. METHODOLOGY/PRINCIPAL FINDINGS:In the present study, using the genome-wide transcriptional profiling of normal and injured sciatic nerves in mice followed by extensive bioinformatics analyses of the data, we determin  ...[more]

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