Dataset Information


Homo sapiens

ABSTRACT: Genome-wide DNA methylation profiling of CpG islands in breast cancer

ORGANISM(S): Homo sapiens  



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Genome-wide DNA methylation profiling of CpG islands in breast cancer identifies novel genes associated with tumorigenicity.

Hill Victoria K VK   Ricketts Christopher C   Bieche Ivan I   Vacher Sophie S   Gentle Dean D   Lewis Cheryl C   Maher Eamonn R ER   Latif Farida F  

Cancer research 20110301 8

Epigenetic profiling of tumor DNAs may reveal important new theranostic targets to improve prognosis and treatment of advanced cancer patients. In this study, we performed a genome-wide profile of DNA methylation patterns in sporadic breast tumors by using the HumanMethylation27 BeadChips to assess relationships between DNA methylation changes and patient tumor characteristics. The arrays identified 264 hypermethylated loci/genes present in genomic CpG islands. Hierarchical clustering based on m  ...[more]

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