Dataset Information


Homo sapiens

ABSTRACT: Reprogramming of human fibroblasts toward a cardiac fate

ORGANISM(S): Homo sapiens  



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Reprogramming of human fibroblasts toward a cardiac fate.

Nam Young-Jae YJ   Song Kunhua K   Luo Xiang X   Daniel Edward E   Lambeth Kaleb K   West Katherine K   Hill Joseph A JA   DiMaio J Michael JM   Baker Linda A LA   Bassel-Duby Rhonda R   Olson Eric N EN  

Proceedings of the National Academy of Sciences of the United States of America 20130304 14

Reprogramming of mouse fibroblasts toward a myocardial cell fate by forced expression of cardiac transcription factors or microRNAs has recently been demonstrated. The potential clinical applicability of these findings is based on the minimal regenerative potential of the adult human heart and the limited availability of human heart tissue. An initial but mandatory step toward clinical application of this approach is to establish conditions for conversion of adult human fibroblasts to a cardiac  ...[more]

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