Dataset Information


Homo sapiens

ABSTRACT: IL-27 Inhibits HIV-1 Infection in Human Macrophages by Down-regulating Host Factor SPTBN1 during Monocyte to Macrophage Differentiation

ORGANISM(S): Homo sapiens  



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IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation.

Dai Lue L   Lidie Kristy B KB   Chen Qian Q   Adelsberger Joseph W JW   Zheng Xin X   Huang DaWei D   Yang Jun J   Lempicki Richard A RA   Rehman Tauseef T   Dewar Robin L RL   Wang Yanmei Y   Hornung Ronald L RL   Canizales Kelsey A KA   Lockett Stephen J SJ   Lane H Clifford HC   Imamichi Tomozumi T  

The Journal of experimental medicine 20130304 3

The susceptibility of macrophages to HIV-1 infection is modulated during monocyte differentiation. IL-27 is an anti-HIV cytokine that also modulates monocyte activation. In this study, we present new evidence that IL-27 promotes monocyte differentiation into macrophages that are nonpermissive for HIV-1 infection. Although IL-27 treatment does not affect expression of macrophage differentiation markers or macrophage biological functions, it confers HIV resistance by down-regulating spectrin β non  ...[more]

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