Dataset Information


Mus musculus

ABSTRACT: TLR4 senses oxidative stress mediated by partially oxidized microvesicles.

ORGANISM(S): Mus musculus  



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Toll-like receptor 4 senses oxidative stress mediated by the oxidation of phospholipids in extracellular vesicles.

Manček-Keber Mateja M   Frank-Bertoncelj Mojca M   Hafner-Bratkovič Iva I   Smole Anže A   Zorko Mateja M   Pirher Nina N   Hayer Silvia S   Kralj-Iglič Veronika V   Rozman Blaž B   Ilc Nejc N   Horvat Simon S   Jerala Roman R  

Science signaling 20150616 381

Oxidative stress produced in response to infection or sterile injury activates the innate immune response. We found that extracellular vesicles (EVs) isolated from the plasma of patients with rheumatoid arthritis or secreted from cells subjected to oxidative stress contained oxidized phospholipids that stimulated cells expressing Toll-like receptor 4 (TLR4) in a manner dependent on its co-receptor MD-2. EVs from healthy subjects or reconstituted synthetic EVs subjected to limited oxidation gaine  ...[more]

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