Dataset Information


Mus musculus

ABSTRACT: C/EBPα poises B cells for rapid reprogramming into iPS cells [array]

ORGANISM(S): Mus musculus  



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C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells.

Di Stefano Bruno B   Sardina Jose Luis JL   van Oevelen Chris C   Collombet Samuel S   Kallin Eric M EM   Vicent Guillermo P GP   Lu Jun J   Thieffry Denis D   Beato Miguel M   Graf Thomas T  

Nature 20131215 7487

CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem (iPS) cells when co-expressed with the transcription factors Oct4 (Pou5f1), Sox2, Klf4 and Myc (hereafter called OSKM). However, how C/EBPα accomplishes these effects is unclear. Here we find that in mouse primary B cells transient C/EBPα expression followed by OSKM activation induces a 100-fold increase in iPS cell repro  ...[more]

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