Genomics

Dataset Information

0

Mus musculus


ABSTRACT: C/EBPα poises B cells for rapid reprogramming into iPS cells [array]

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA198734 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

C/EBPα poises B cells for rapid reprogramming into induced pluripotent stem cells.

Di Stefano Bruno B   Sardina Jose Luis JL   van Oevelen Chris C   Collombet Samuel S   Kallin Eric M EM   Vicent Guillermo P GP   Lu Jun J   Thieffry Denis D   Beato Miguel M   Graf Thomas T  

Nature 20131215 7487


CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem (iPS) cells when co-expressed with the transcription factors Oct4 (Pou5f1), Sox2, Klf4 and Myc (hereafter called OSKM). However, how C/EBPα accomplishes these effects is unclear. Here we find that in mouse primary B cells transient C/EBPα expression followed by OSKM activation induces a 100-fold increase in iPS cell repro  ...[more]

Similar Datasets

| PRJNA227547 | ENA
| PRJNA227774 | ENA
| PRJNA227776 | ENA
2014-01-01 | S-EPMC4322579 | BioStudies
2013-01-01 | S-EPMC3841145 | BioStudies
2013-11-17 | E-GEOD-52397 | ArrayExpress
1000-01-01 | S-EPMC6168588 | BioStudies
2013-11-17 | E-GEOD-52373 | ArrayExpress
2013-01-01 | S-EPMC4100556 | BioStudies
2013-11-17 | E-GEOD-52396 | ArrayExpress