Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Expression data from FACS purified nociceptor neurons from peripheral sensory ganglia

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA200949 | ENA |

REPOSITORIES: ENA

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Publications


Nociceptor sensory neurons are specialized to detect potentially damaging stimuli, protecting the organism by initiating the sensation of pain and eliciting defensive behaviours. Bacterial infections produce pain by unknown molecular mechanisms, although they are presumed to be secondary to immune activation. Here we demonstrate that bacteria directly activate nociceptors, and that the immune response mediated through TLR2, MyD88, T cells, B cells, and neutrophils and monocytes is not necessary  ...[more]

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