Genomics,Multiomics

Dataset Information

0

Mus musculus


ABSTRACT: Prefrontal cortex gene expression in WSP and WSR male and female mice following 72h of chronic ethanol vapor exposure

OTHER RELATED OMICS DATASETS IN: E-GEOD-56249E-GEOD-56247

PROVIDER: PRJNA242779 | ENA |

REPOSITORIES: ENA

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Publications

Understanding the addiction cycle: a complex biology with distinct contributions of genotype vs. sex at each stage.

Wilhelm C J CJ   Hashimoto J G JG   Roberts M L ML   Sonmez M K MK   Wiren K M KM  

Neuroscience 20140904


Ethanol abuse can lead to addiction, brain damage and premature death. The cycle of alcohol addiction has been described as a composite consisting of three stages: intoxication, withdrawal and craving/abstinence. There is evidence for contributions of both genotype and sex to alcoholism, but an understanding of the biological underpinnings is limited. Utilizing both sexes of genetic animal models with highly divergent alcohol withdrawal severity, Withdrawal Seizure-Resistant (WSR) and Withdrawal  ...[more]

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