Dataset Information


Saccharomyces cerevisiae

ABSTRACT: Expression data from yeast heterologously expressing αENaC, CFTR or Kir2.1 [αENaC]

ORGANISM(S): Saccharomyces cerevisiae  



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Expression of three topologically distinct membrane proteins elicits unique stress response pathways in the yeast Saccharomyces cerevisiae.

Buck Teresa M TM   Jordan Rick R   Lyons-Weiler James J   Adelman Joshua L JL   Needham Patrick G PG   Kleyman Thomas R TR   Brodsky Jeffrey L JL  

Physiological genomics 20150310 6

Misfolded membrane proteins are retained in the endoplasmic reticulum (ER) and are subject to ER-associated degradation, which clears the secretory pathway of potentially toxic species. While the transcriptional response to environmental stressors has been extensively studied, limited data exist describing the cellular response to misfolded membrane proteins. To this end, we expressed and then compared the transcriptional profiles elicited by the synthesis of three ER retained, misfolded ion cha  ...[more]

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