Genomics

Dataset Information

294

Mus musculus


ABSTRACT: Comparative Analysis of the hippocampal transcriptome of WT and NONO KO mice

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA264457 | ENA |

REPOSITORIES: ENA

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Publications


The NONO protein has been characterized as an important transcriptional regulator in diverse cellular contexts. Here we show that loss of NONO function is a likely cause of human intellectual disability and that NONO-deficient mice have cognitive and affective deficits. Correspondingly, we find specific defects at inhibitory synapses, where NONO regulates synaptic transcription and gephyrin scaffold structure. Our data identify NONO as a possible neurodevelopmental disease gene and highlight the  ...[more]

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