Project description:Mycobacterium avium subspecies paratuberculosis (MAP) causes chronic progressive granulomatous enteritis leading to diarrhea, weight loss, and eventual death in ruminants. Commercially available vaccines provide only partial protection against MAP infection and can interfere with the use of current diagnostic tests for bovine tuberculosis in cattle. In the current study, we characterized immune responses in calves to vaccines containing either MAP fusion protein particles (MAP antigens Ag85A202-347-SOD1-72 -Ag85B173-330-74F1-148+669-786 as a fusion), recombinant MAP (rMAP) fusion protein or commercially available Silirum(R) vaccine.

2022-12-21 | GSE221544 | GEO

Homo sapiens

Project description:Genome wide gene expression analysis of chronic granulomatous disease patients

| PRJNA192662 | ENA

Francisella philomiragia subsp. philomiragia ATCC 25015 strain:O#319L

Project description:Francisella philomiragia O#319L Genome sequencing

| PRJNA239335 | ENA

Homo sapiens

Project description:NIH/NIAID Chronic Granulomatous Disease Neutrophils

| PRJNA87967 | ENA

Secretome Analysis of Mycobacterial-infected Bovine Macrophages

Project description:Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, a chronic granulomatous disease. Mtb is mostly restricted to humans and seldom causes disease in animals. M. bovis (Mbv) on the other hand causes tuberculosis in cows (bovine tuberculosis) and several wild animals. Each of these pathogens therefore has unique host adaptations and the host- and pathogen-specific factors driving this differential tropism still remain largely unknown. Here we profiled the secretomes of Mtb- and Mbv-infected bovine macrophages to characterise host-specific responses to each pathogen.

2021-03-11 | PXD017949 | Pride

Genome wide gene expression analysis of chronic granulomatous disease patients

Project description:Whole blood was collected from chronic granulomatous patients, carriers and healthy controls.

2014-11-01 | GSE44969 | GEO