Genomics

Dataset Information

118

Homo sapiens


ABSTRACT: Genome-wide map of H3K4me3 before and after methionine restriction in HCT116 cells.

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA293125 | ENA |

REPOSITORIES: ENA

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Publications


S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) link one-carbon metabolism to methylation status. However, it is unknown whether regulation of SAM and SAH by nutrient availability can be directly sensed to alter the kinetics of key histone methylation marks. We provide evidence that the status of methionine metabolism is sufficient to determine levels of histone methylation by modulating SAM and SAH. This dynamic interaction led to rapid changes in H3K4me3, altered gene transcription  ...[more]

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