Dataset Information


Mus musculus

ABSTRACT: RNA sequencing of ID4-GFP Bright and ID4-GFP Dim spermatogonia from postnatal day 8 transgenic Id4-Gfp (LT11) mouse pups



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Action DRS
SRR5189930_1.fastq.gz Fastqsanger.gz
SRR5189930_2.fastq.gz Fastqsanger.gz
SRR5189921_1.fastq.gz Fastqsanger.gz
SRR5189921_2.fastq.gz Fastqsanger.gz
SRR5189931_1.fastq.gz Fastqsanger.gz
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ID4 levels dictate the stem cell state in mouse spermatogonia.

Helsel Aileen R AR   Yang Qi-En QE   Oatley Melissa J MJ   Lord Tessa T   Sablitzky Fred F   Oatley Jon M JM  

Development (Cambridge, England) 20170113 4

Spermatogenesis is a classic model of cycling cell lineages that depend on a balance between stem cell self-renewal for continuity and the formation of progenitors as the initial step in the production of differentiated cells. The mechanisms that guide the continuum of spermatogonial stem cell (SSC) to progenitor spermatogonial transition and precise identifiers of subtypes in the process are undefined. Here we used an <i>Id4-eGfp</i> reporter mouse to discover that EGFP intensity is predictive  ...[more]

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