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Expression data from hair follicles treated with an osteopontin-derived peptide

ABSTRACT: Expression data from hair follicles treated with an osteopontin-derived peptide

PROVIDER: PRJNA420989 | ENA |

REPOSITORIES: ENA

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Expression data from hair follicles treated with an osteopontin-derived peptide

Project description:The human hair follicle is not only regulated, but is a source of transcription factors, hormones, neurohormones etc. which are crucial in regulating its growth. We used microarrays to determine the early response of microdissected human hair follicles to an osteopontin-derived peptide.

2017-12-05 | GSE107663 | GEO

FGF18 Signaling for Hair Cycle Resting Phase Determines Radioresistance of Hair Follicles by the Arrest of Hair Cycling

Project description:Telogen (resting phase) hair follicles are more radioresistant than anagen (growth phase) ones. Irradiation of BALB/c mice in the anagen phase with γ-rays at 6 Gy induced hair follicle dystrophy, whereas irradiation in the telogen phase induced the arrest of hair follicle elongation without any dystrophy after post-irradiation depilation. In contrast, FGF18 was highly expressed in the telogen hair follicles to maintain the telogen phase and also the quiescence of hair follicle stem cells. Therefore, the inhibition of FGF receptor signaling at telogen induced the dystrophy after post-irradiation depilation. In addition, the administration of recombinant FGF18 suppressed cell proliferation in the hair follicles and enhanced the repair of radiation-induced DNA damage, so FGF18 protected the anagen hair follicles against radiation damage to enhance hair regeneration. Moreover, FGF18 reduced the expression of cyclin B1 and cdc2 in the skin and FGF18 signaling induced G2/M arrest in the keratinocyte cell line HaCaT, although no obvious change of the expression of DNA repair genes was detected by DNA microarray analysis. These findings suggest that FGF18 signaling for the hair cycle resting phase causes radioresistance in telogen hair follicles by arresting the proliferation of hair follicle cells.

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Human Hair follicles: Control Vs. 0.5 µM spermidine treatment

Project description:To compare the effects of spermidine, key polyamine, on the gene expression profile of organ cultured human hair follicles Vehicle treated Vs. 0.5 µM spermidine treatment. Two control samples, two spermidine treated samples

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Next generation sequence analysis of cells derived from mouse hair follicles after long term culture

Project description:Follicle epithelial stem cells (HFSCs) have important functions for homeostasis of skin as well as hair follicle morphogenesis. In the present study, we screened different types of commercially available culture medium for culturing HFSCs. Among those tested, one type was shown capable of supporting the expression of stem cell markers in cultured HFSCs. However, the differentiation ability of HFSCs serially passaged using that optimal medium was found to be impaired, leading to unsuccessful formation of hair follicles in vivo.

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Effect of GMG-43-AC on hair follicles

Project description:In recent years, there is a growing interest in the role of PPARγ agonists in skin biology. Specifically, we have previously shown that agonistic PPARγ modulators affect hair follicle growth and function. PPARγ-mediated signalling has also been implicated in the regulation of mitochondrial energy metabolism in several tissues (adipose and brain), but how PPARγ-stimulation affects mitochondrial biology in the skin is still unknown. In this study, we aimed to explore the effects of PPARγ-stimulation in organ cultured human hair follicles.

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