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Defining DC response to cognate T cell interaction in the antigen-challenged lymph node [dataset 3]

ABSTRACT: Defining DC response to cognate T cell interaction in the antigen-challenged lymph node [dataset 3]

PROVIDER: PRJNA530542 | ENA |

REPOSITORIES: ENA

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Defining DC response to cognate T cell interaction in the antigen-challenged lymph node [dataset 3]

Project description:We designed an experimental set up to probe DC responses to cognate T cell encounter in antigen draining LN

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Project description: Not available

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Cognate T cell interactions affect the DC transcriptome [dataset 4]

Project description:Cognate T cell interactions affect the DC transcriptome [dataset 4]

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Project description:Our data suggest that peptide-presenting DC receive signals from synapse-forming antigen specific CD4+ or CD8+ T cells that alter the DC expression profile. To further test this notion, we hock immunized T cell-engrafted mice with NP harboring CpG and coated with OVA (OVA / CpG NP) or the control antigen BSA (BSA / CpG NP) and isolated NP+ DC for RNAseq.

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