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The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1

ABSTRACT: The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1

PROVIDER: PRJNA554208 | ENA |

REPOSITORIES: ENA

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The RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1

Project description:The RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1

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The RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1 [RNA-seq]

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The RNA hairpin binder TRIM71 modulates alternative splicing by repressing Mbnl1

Project description:We demonstrate that global effects of TRIM71 on the cellular transcriptome of mouse embryonic stem cells (mESCs) are largely attributable to its RNA binding activity, and map the transcriptome-wide targets of wild-type TRIM71, NHL domain mutant TRIM71, and RING domain mutant TRIM71.

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The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1.

Project description: Not available

| S-EPMC6719626 | biostudies-literature

The RNA hairpin binder TRIM71 modulates alternative splicing by repressing MBNL1

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-08-01 | GSE134125 | GEO

MBNL1-dependent modulation of transcript stability

Project description:In order to identify MBNL1-dependent changes in MBNL1 target transcript stability, MBNL1 levels in MDA-MB-231 breast cancer cells were stably knocked-down using short-hairpin RNAs. The cells were then treated with alpha-amanitin to inhibit transcription, RNA was isolated at 0 and 9 hours post-alpha-amanitin treatment, and the samples were transcriptomically profiled.

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mRNA sequencing of Trim71 conditional ("WT") and Trim71 KO mES cells

Project description:We report that Trim71 mutation does not lead to significant changes within the core regulatory network of mES cells, however, there is an upregulation of specific genes involved in neural differentiation. We thus conclude that Trim71 KO mES cells are poised for differentiation.

2015-10-01 | GSE62398 | GEO

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