Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Ileum Transcriptomic Profiling in Inflammatory Bowel Disease

ABSTRACT: Ileum Transcriptomic Profiling in Inflammatory Bowel Disease

PROVIDER: PRJNA565216 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Ileum Transcriptomic Profiling in Inflammatory Bowel Disease

Project description:We report ileum gene expression of 37 controls and 158 patients with either Crohn's disease (n=112), ulcerative colitis (n=44), unclassifed IBD (1), or IBS (1). We contrast gene expression in African American (n=104) versus white (n=25) CD and UC patients.

2020-04-15 | GSE137344 | GEO

Transcription profiling of human intestinal epithilium in patients suffering from inflammatory bowel disease.

Project description:Identification of significant regulated genes in the intestinal epithelium (ileum and colon) <br>in patients suffering from inflammatory bowel disease (normal vs. activ and non-activ <br>Crohn's disease and Ulcerative Colitis). This experiment is an extension of experiment E-MEXP-1225. We added 12 new hybridizations prepared according to amplification, hybridization and normalization protocols described in E-MEXP-1225.

2010-01-01 | E-MEXP-2083 | biostudies-arrayexpress

Expression profiling in inflammatory bowel disease

Project description:The series was designed to identify new genes involved in the pathophysiology of inflammatory bowel disease (Crohn's disease and ulcerative colitis). This series represents a group of 31 samples, subdivided into 3 groups: 1) Normal controls: 11 samples; 2) patients with Crohn's diseases: 10 samples; 3) patients with ulcerative colitis: 10 samples. Each sample originated from a different patient or normal control, in total n=31 individuals were examined. Keywords = Inflammatory bowel disease Keywords = Crohn's disease Keywords = ulcerative colitis Keywords = expression screening Keywords = expression profiling Keywords: other

2005-08-11 | GSE1710 | GEO

Embark cross-sectional study of inactive and active lesions from the ileum and colon of inflammatory bowel disease patients

Project description:Hypothesis: Gene expression differences in biopsies from patients with inflammatory bowel disease can be used to identify molecular heterogeneity within patients with active disease. Methods: Patients with a diagnosis of Crohn's disease, ulcerative colitis or normal healthy controls (with or without infectious colitis) underwent ileocolonoscopy. In healthy controls, biopsies were taken in the sigmoid colon (n=21), ascending/descending colon (n=25) and the terminal ileum (n=12). In patients with Crohn's disease, biopsies were taken in the ascending/descending colon (n=107) and terminal ileum (n=70) in uninflamed areas in all patients; in patients with mucosal lesions, additional biopsies were taken in inflamed regions of the ascending/descending colon (n=35) and terminal ileum (n=55). In ulcerative colitis patients, paired uninflamed sigmoid (n=48) and inflamed sigmoid biopsies (n=46) were taken. Biopsies were placed in RNAlater at the clinical site, frozen and shipped to Genentech, where they were disrupted using TissueLyzer beads, then RNA was isolated using RNeasy columns. RNA was hybridized to Agilent human 4x44kv1 arrays, dual channel, using universal reference.

2021-07-26 | GSE179285 | GEO

Inflammatory Bowel Disease StOlav

Project description:Expression profiling of human colon mucosa samples aquired from inflammatory bowel disease patients and healthy controls. Expression profiling was done using Illumina Human HT-12 arrays, and data analysis was performed using tools from the Bioconductor package

2012-09-12 | E-MTAB-184 | biostudies-arrayexpress

Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease

Project description:Dysregulated proteolysis plays a pivotal role in the pathophysiology of inflammatory bowel disease. Nonetheless, the identity of overactive proteases released by human colonic mucosa remains unknown. Herein, we employed a serine protease-targeted activity-based probe (ABP) coupled with mass spectral analysis to identify active forms of proteases secreted by the colonic mucosa of healthy volunteers and inflammatory bowel disease patients. With this approach, we identified seven active serine proteases: cathepsin G, plasma kallikrein, plasmin, tryptase, chymotrypsin-like elastase 3A, aminopeptidase B, and thrombin. Furthermore, cathepsin G and thrombin were overactive in supernatants from inflammatory bowel disease patients once compared to healthy volunteers.

2018-05-18 | PXD009450 | Pride

Gut Microbial Ecosystem Multiomics in Inflammatory Bowel Disease

Project description:Using multiple omics approaches to explore the effect of the gut microbial ecosytem on inflammatory bowel disease

2019-07-02 | MSV000084050 | MassIVE

Gut Microbial Ecosystem Multiomics in Inflammatory Bowel Disease

Project description:Using multiple omics approaches to explore the effect of the gut microbial ecosytem on inflammatory bowel disease

2019-04-05 | PXD008675 | Pride

Inflammatory Bowel Disease Immunochip from NIDDK repository

Project description:Inflammatory Bowel Disease Immunochip from NIDDK repository

| PRJNA498170 | ENA

Inflammatory Bowel Disease Immunochip from NIDDK repository

Project description:Inflammatory Bowel Disease Immunochip from NIDDK repository