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Adipose derived stem cells (ASCs) methylation differences between Crohn Disease and No-Crohn individuals

ABSTRACT: Adipose derived stem cells (ASCs) methylation differences between Crohn Disease and No-Crohn individuals

PROVIDER: PRJNA575496 | ENA |

REPOSITORIES: ENA

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Adipose derived stem cells (ASCs) methylation differences between Crohn Disease and No-Crohn individuals

Project description:Pathological expansion of adipose tissue (AT) is supported by adipocyte precursors, termed adipose-derived stem cells (ASCs). Elucidation of mechanisms underlying ASC function may lead to therapeutic interventions to use in cell therapy treatments on Crohn’s disease patients. Using epigenome-wide association studies, we explored the impact of Crohn’s disease on the methylation signature of human ASCs

2019-10-03 | GSE138311 | GEO

Adipose derived stem cells (ASCs) methylation differences between lean and obese individuals

Project description:Adipose derived stem cells (ASCs) methylation differences between lean and obese individuals

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Adipose derived stem cells (ASCs) methylation differences between lean and obese individuals

Project description:Pathological expansion of adipose tissue (AT) in obesity is supported by adipocyte precursors, termed adipose-derived stromal/stem cells (ASCs). Elucidation of mechanisms underlying ASC function may lead to therapeutic interventions to treat fat mass accumulation. Using epigenome-wide association studies, we explored the impact of obesity on the methylation signature of human ASCs.

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Microarray for density study of mouse Adipose-derived Stromal Cells (ASCs)

Project description:Cytoskeletal tension is an intracellular mechanism through which cells convert a mechanical signal into a biochemical response, including production of cytokines and activation of various signaling pathways. Adipose-derived stromal cells (ASCs) were allowed to spread into large cells by seeding them at a low-density (1,250 cells/cm2), which was observed to induce osteogenesis. Conversely, ASCs seeded at a high-density (25,000 cells/cm2) featured small cells that promoted adipogenesis. RhoA and actin filaments were altered by changes in cell size. Blocking actin polymerization by Cytochalasin D influenced cytoskeletal tension and differentiation of ASCs. To understand the potential regulatory mechanisms leading to actin cytoskeletal tension, cDNA microarray was performed on large and small ASCs. Connective tissue growth factor (CTGF) was identified as a major regulator of osteogenesis associated with RhoA mediated cytoskeletal tension. Subsequently, knock-down of CTGF by siRNA in ASCs inhibited this osteogenesis. Therefore, we conclude that cytoskeletal tension is important for CTGF-regulated ASC osteogenic differentiation. Computed

2011-01-16 | E-GEOD-19924 | biostudies-arrayexpress

Microarray for density study of mouse Adipose-derived Stromal Cells (ASCs)

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Comparison of WAT EPCs vs WAT ASCs

Project description:Human adipose tissue contains two populations of progenitors (EPCs and ASCs) with cooperative roles in breast cancer. EPCs (CD45-CD34+CD31+CD13-CCRL2+) can generate endothelial cells. ASCs (CD45-CD34+CD31-CD13+CD140b+) are mesenchymal progenitors which generated pericytes. CD13+ cells and CD13- cells from 7 Lipotransfer aspirate

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Comparison of WAT EPCs vs WAT ASCs

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MicroRNA Sequencing of CD34+ Sorted Adipose Stem Cells (ASCs) Undergoing Endotheliogenesis

Project description:MicroRNA Sequencing of CD34+ Sorted Adipose Stem Cells (ASCs) Undergoing Endotheliogenesis

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MicroRNA Sequencing of CD34+ Sorted Adipose Stem Cells (ASCs) Undergoing Endotheliogenesis

Project description:In this study, CD34+ ASCs sorted using magnetic bead separation were induced to differentiate along the endothelial pathway. miRNA sequencing of ASCs at day 3, 9 and 14 of endothelial differentiation was performed on Ion Proton sequencing system. The data obtained by this high-throughput method was aligned to the human genome HG38 and the differentially expressed miRNAs during endothelial differentiation at various timepoints (day 3, 9 and 14) were identified.

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Expression data from Adipose Stem Cells (ASC) from morbidly obese and non-obese individuals

Project description:The adipose tissue is an endocrine regulator and a risk factor for atherosclerosis and cardiovascular disease when by excessive accumulation induces obesity. Although the adipose tissue is also a reservoir for stem cells (ASC) their function and “stemcellness” has been questioned. Our aim was to investigate the mechanisms by which obesity affects subcutaneous white adipose tissue (WAT) stem cells. We used microarrays to analyze differences in transcriptomic profiles between the adipose stem cells from morbidly obese and non-obese individuals.

2013-09-17 | GSE48964 | GEO

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