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Chromatin profiling of the relationship between EWS/FLI, LSD1, and H3K27 acetylation

ABSTRACT: Chromatin profiling of the relationship between EWS/FLI, LSD1, and H3K27 acetylation

PROVIDER: PRJNA604452 | ENA |

REPOSITORIES: ENA

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Chromatin profiling of the relationship between EWS/FLI, LSD1, and H3K27 acetylation

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Project description:The purpose of this study was to define unique classes of EWS/FLI target genes and the distinct set of structural features present in the EWS domain required for target gene regulation at different EWS/FLI response elements. This study reports the first genome-wide transcriptomic description of a partially-functional EWS/FLI mutant . We report new structure-function dependencies across different classes of response element and tie these dependencies to the ability of EWS/FLI to transform cells.

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Chromatin profiling of the relationship between EWS/FLI, LSD1, and the enhancer landscape - H3K4 methylation

Project description:Chromatin profiling of the relationship between EWS/FLI, LSD1, and the enhancer landscape - H3K4 methylation

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EWS/FLI mediated reprogramming of 3D chromatin promotes an altered transcriptional state in Ewing sarcoma (4C)

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