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Epigenome analysis of HDAC1 stably knocked down HCT116 cell [Illumina EPIC]

ABSTRACT: Epigenome analysis of HDAC1 stably knocked down HCT116 cell [Illumina EPIC]

PROVIDER: PRJNA637513 | ENA |

REPOSITORIES: ENA

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Epigenome analysis of HDAC1 stably knocked down HCT116 cell [Illumina EPIC]

Project description:UHRF1 is a key regulator of DNA methylation maintenance. In this study, we investigated whether acetylation of UHRF1 affects its hemimethylated DNA binding affinity and alters genome-wide DNA methylation pattern. We observed that acetylation of UHRF1 is regulated by HDAC1 and PCAF. We investigated DNA methylation profile of HDAC1 depleted HCT116 cell with control cell.

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Project description:Epigenome analyses of HCT116 cells stably expressing UHRF1 mutant [Illumina EPIC]

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Epigenome analysis of HDAC1 stably knocked down HCT116 cells and HCT116 cells stably expressing UHRF1 mutant

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