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Changes in gene expression over time in cells expressing t(4;11) fusion proteins

ABSTRACT: Changes in gene expression over time in cells expressing t(4;11) fusion proteins

PROVIDER: PRJNA739158 | ENA |

REPOSITORIES: ENA

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Changes in chromatin accessibility over time in cells expressing t(4;11) fusion proteins

Project description:Changes in chromatin accessibility over time in cells expressing t(4;11) fusion proteins

| PRJNA739665 | ENA

Changes in chromatin accessibility over time in cells expressing t(4;11) fusion proteins [I]

Project description:Changes in chromatin accessibility over time in cells expressing t(4;11) fusion proteins [I]

| PRJNA739668 | ENA

Changes in chromatin accessibility over time in cells expressing t(4;11) fusion proteins [II]

Project description:Changes in chromatin accessibility over time in cells expressing t(4;11) fusion proteins [II]

| PRJNA739670 | ENA

Changes in gene expression over time in cells expressing t(4;11) fusion proteins

Project description:We have used a constitutive MLL-AF4 fusion gene together with a inducible AF4-MLL fusion gene to investigate the power of theses fusion proteins. All transgenes were stably or transiently transfected.

2021-06-19 | GSE178465 | GEO

Changes in chromatin accessibility over time in cells expressing t(4;11) fusion proteins [I]

2021-06-22 | GSE178567 | GEO

Changes in chromatin accessibility over time in cells expressing t(4;11) fusion proteins [II]

Project description:We have used a combination of constitutive and inducible MLL-AF4 and AF4-MLL fusion genes to investigate the power of theses fusion proteins. All transgenes were stably or transiently transfected. Here, we compared 48 induction of MLL-AF4 or AF4-MLL (day 3) and looked for persistance at days 28. This was compared to the situation with constitutive MLL-AF4 with 48 inductionn of AF4-MLL at day 3 and day 28.

2021-06-22 | GSE178568 | GEO

Instructive role of MLL fusion proteins revealed by a faithful model of t(4;11) proB acute lymphoblastic leukemia

Project description:The t(4;11)(q21;q23) fuses MLL to AF4, the most common MLL fusion partner. Here we show that MLL fused to murine Af4, highly conserved with human AF4, produces high-titer retrovirus permitting efficient transduction of human CD34+ cells to generate a faithful model of t(4;11) proB ALL that fully recapitulates the immunophenotypic and molecular aspects of the disease. MLL-Af4 induces a distinct B-ALL from MLL-AF9 through differential DNA binding of the fusion proteins leading to specific gene expression patterns. MLL-Af4 cells can assume a myeloid state under environmental pressure but retain lymphoid-lineage potential. We observed this incongruity in t(4;11) patients who evaded CD19-directed therapy by undergoing myeloid-lineage switch. Our model provides a valuable tool to unravel the pathogenesis of MLL-AF4 leukemogenesis.

2016-11-23 | GSE84116 | GEO

Changes in chromatin accessibility over time in cells expressing t(4;11) fusion proteins

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-06-22 | GSE178569 | GEO

Changes in gene expression when expressing two sets of t(6;11) fusion proteins

Project description:Changes in gene expression when expressing two sets of t(6;11) fusion proteins

| PRJNA732920 | ENA

Changes in chromatin accessibility when expressing two sets of t(6;11) fusion proteins

Project description:Changes in chromatin accessibility when expressing two sets of t(6;11) fusion proteins

| PRJNA732711 | ENA