Dataset Information


Mus musculus

ABSTRACT: Simulated Microgravity Inhibits Differentiation and Alters Gene Expression Profiles of 2T3 Pre-osteoblasts

ORGANISM(S): Mus musculus  



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Identification of mechanosensitive genes in osteoblasts by comparative microarray studies using the rotating wall vessel and the random positioning machine.

Patel Mamta J MJ   Liu Wenbin W   Sykes Michelle C MC   Ward Nancy E NE   Risin Semyon A SA   Risin Diana D   Jo Hanjoong H  

Journal of cellular biochemistry 20070601 3

Weightlessness or microgravity of spaceflight induces bone loss due in part to decreased bone formation by unknown mechanisms. Due to difficulty in performing experiments in space, several ground-based simulators such as the Rotating Wall Vessel (RWV) and Random Positioning Machine (RPM) have become critical venues to continue studying space biology. However, these simulators have not been systematically compared to each other or to mechanical stimulating models. Here, we hypothesized that expos  ...[more]

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