Dataset Information


Saccharomyces cerevisiae

ABSTRACT: TFIIH mutants treated with methyl methanesulfonate

ORGANISM(S): Saccharomyces cerevisiae  



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Ubiquitin ligase activity of TFIIH and the transcriptional response to DNA damage.

Takagi Yuichiro Y   Masuda Claudio A CA   Chang Wei-Hau WH   Komori Hirofumi H   Wang Dong D   Hunter Tony T   Joazeiro Claudio A P CA   Kornberg Roger D RD  

Molecular cell 20050401 2

Core transcription factor (TF) IIH purified from yeast possesses an E3 ubiquitin (Ub) ligase activity, which resides, at least in part, in a RING finger (RNF) domain of the Ssl1 subunit. Yeast strains mutated in the Ssl1 RNF domain are sensitive to ultraviolet (UV) light and to methyl methanesulfonate (MMS). This increased sensitivity to DNA-damaging agents does not reflect a deficiency in nucleotide excision repair. Rather, it correlates with reduced transcriptional induction of genes involved  ...[more]

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