Proteomics

Dataset Information

0

Ancient fossil bone sequencing


ABSTRACT: Not available

INSTRUMENT(S): instrument model, LTQ

ORGANISM(S): Mammut Americanum (american Mastodon)

SUBMITTER: John Asara  

PROVIDER: PRD000088 | Pride | 2009-07-28

REPOSITORIES: Pride

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Publications

Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry.

Asara John M JM   Schweitzer Mary H MH   Freimark Lisa M LM   Phillips Matthew M   Cantley Lewis C LC  

Science (New York, N.Y.) 20070401 5822


Fossilized bones from extinct taxa harbor the potential for obtaining protein or DNA sequences that could reveal evolutionary links to extant species. We used mass spectrometry to obtain protein sequences from bones of a 160,000- to 600,000-year-old extinct mastodon (Mammut americanum) and a 68-million-year-old dinosaur (Tyrannosaurus rex). The presence of T. rex sequences indicates that their peptide bonds were remarkably stable. Mass spectrometry can thus be used to determine unique sequences  ...[more]

Publication: 1/4

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