Dataset Information

LC-MS/MS of cultured Mycobacterium tuberculosis in a hypoxia/reaeration timecourse

ABSTRACT: Mycobacterium tuberculosis samples were collected during oxygen starvation and reaeration. The samples were solubized with urea, digested with trypsin, then desalted with a C18 96-well plate prior to LC-MS/MS analysis.

REANALYSED by: PAe004062

OTHER RELATED OMICS DATASETS IN: PAe004063PRJNA186476

INSTRUMENT(S):

ORGANISM(S): Mycobacterium Tuberculosis

SUBMITTER: Gingras Olivier

LAB HEAD: Gingras Olivier

PROVIDER: PXD000045 | Pride | 2013-06-25

REPOSITORIES: Pride

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			Action	DRS
	CZCV20621G11101XMS.RAW.ZIP	Raw
	CZCV20821G11101XMS.RAW.ZIP	Raw
	CZCV21021G11101XMS.RAW.ZIP	Raw
	CZCV21421G11101XMS.RAW.ZIP	Raw
	CZCV21621G11101XMS.RAW.ZIP	Raw

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Publications

The Mycobacterium tuberculosis regulatory network and hypoxia.

Galagan James E JE Minch Kyle K Peterson Matthew M Lyubetskaya Anna A Azizi Elham E Sweet Linsday L Gomes Antonio A Rustad Tige T Dolganov Gregory G Glotova Irina I Abeel Thomas T Mahwinney Chris C Kennedy Adam D AD Allard René R Brabant William W Krueger Andrew A Jaini Suma S Honda Brent B Yu Wen-Han WH Hickey Mark J MJ Zucker Jeremy J Garay Christopher C Weiner Brian B Sisk Peter P Stolte Christian C Winkler Jessica K JK Van de Peer Yves Y Iazzetti Paul P Camacho Diogo D Dreyfuss Jonathan J Liu Yang Y Dorhoi Anca A Mollenkopf Hans-Joachim HJ Drogaris Paul P Lamontagne Julie J Zhou Yiyong Y Piquenot Julie J Park Sang Tae ST Raman Sahadevan S Kaufmann Stefan H E SH Mohney Robert P RP Chelsky Daniel D Moody D Branch DB Sherman David R DR Schoolnik Gary K GK

Nature 20130703 7457

We have taken the first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq and combined this reconstruction with system-wide profiling of messenger RNAs, proteins, metabolites and lipids during hypoxia and re-aeration. Adaptations to hypoxia are thought to have a prominent role in M. tuberculosis pathogenesis. Using ChIP-Seq combined with expression data from the induction of the same factors, we have reconstructed a draft regulatory ne ...[more]

PMID: 23823726

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