High precision platelet releasate definition by quantitative reversed protein profiling
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, instrument model
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Platelet
SUBMITTER: 
Patrick Wijten
PROVIDER: PXD000072 | Pride | 2014-02-03
REPOSITORIES: Pride
Publications
High precision platelet releasate definition by quantitative reversed protein profiling--brief report.
Wijten Patrick P van Holten Thijs T Woo Liy Liy LL Bleijerveld Onno B OB Roest Mark M Heck Albert J R AJ Scholten Arjen A
Arteriosclerosis, thrombosis, and vascular biology 20130502 7
<h4>Objective</h4>Platelet activation and subsequent protein release play an important role in healthy hemostasis and inflammatory responses, yet the identity and quantity of proteins in the platelet releasate are still debated. Here, we present a reversed releasate proteomics approach to determine unambiguously and quantitatively proteins released from activated platelets.<h4>Approach and results</h4>Isolated platelets were mock and fully stimulated after which the released proteins in the supe ...[more]
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