Mercury Uniquely Alters B-Cell Protein Phosphorylation Profiles
Ontology highlight
ABSTRACT:
INSTRUMENT(S): instrument model, LTQ
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): B Cell, Wehi-231 Cell, Blood
SUBMITTER: 
Nicholas Carruthers
PROVIDER: PXD000312 | Pride | 2013-12-10
REPOSITORIES: Pride
Publications
Mercury alters B-cell protein phosphorylation profiles.
Caruthers Nicholas J NJ Stemmer Paul M PM Shin Namhee N Dombkowski Alan A Caruso Joseph A JA Gill Randal R Rosenspire Allen A
Journal of proteome research 20131204 2
Environmental exposure to mercury is suggested to contribute to human immune dysfunction. To shed light on the mechanism, we identified changes in the phosphoproteomic profile of the WEHI-231 B cell line after intoxication with Hg(2+). These changes were compared to changes in the phosphoproteome that were induced by pervanadate or okadaic acid exposure. Both 250 μM HgCl2 and pervanadate, a known phosphotyrosine phosphatase inhibitor, caused an increase in the number of proteins identified after ...[more]
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