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Discovery-Based Protein Expression Profiling Identifies Distinct Subgroups and Pathways in Leiomyosarcomas

ABSTRACT: 20 tumor samples run in duplicates, consisting of pleomorphic sarcomas; classfied as leiomyosarcoma or high-grade undifferentiated pleomorphic sarcoma.

INSTRUMENT(S): instrument model, LTQ Orbitrap XL

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Soft Tissue Sarcoma Cell

SUBMITTER: Ufuk Kirik

LAB HEAD: Ana Carneiro

PROVIDER: PXD000616 | Pride | 2020-01-27

REPOSITORIES: Pride

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Discovery-based protein expression profiling identifies distinct subgroups and pathways in leiomyosarcomas.

Kirik Ufuk U Hansson Karin K Krogh Morten M Jönsson Mats M Nilbert Mef M James Peter P Carneiro Ana A

Molecular cancer research : MCR 20140728 12

<h4>Unlabelled</h4>Soft tissue sarcomas (STS) are malignant tumors of mesenchymal origin. A substantial portion of these tumors exhibits complex karyotypes and lack characterized chromosomal aberrations. Owing to such properties, both histopathologic and molecular classification of these tumors has been a significant challenge. This study examines the protein expression of a large number of human STS, including subtype heterogeneity, using two-dimensional gel proteomics. In addition, detailed pr ...[more]

PMID: 25069693

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